Ubiquitin Like Protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response short title: “UBL-5 and the UPR” Key words: Protein folding, chaperones, organelle, signaling, genetic screen
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چکیده
short title: " UBL-5 and the UPR mt "
منابع مشابه
Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response.
Perturbation of the protein-folding environment in the mitochondrial matrix selectively upregulates the expression of nuclear genes encoding mitochondrial chaperones. To identify components of the signal transduction pathway(s) mediating this mitochondrial unfolded protein response (UPR(mt)), we first isolated a temperature-sensitive mutation (zc32) that conditionally activates the UPR(mt) in C...
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تاریخ انتشار 2006